As peptide therapies move toward the market, efficient and cost effective large scale production becomes essential. Liquid Phase Peptide Synthesis (LPPS) is increasingly adopted for peptide API manufacturing thanks to its scalability and more sustainable profile, with reduced solvent use. At FIS, we support the transition from clinical development to commercial supply with robust LPPS capabilities, designed for projects where purity, cost control, and scale matter.
Discover how we do it through the voices of our experts.
Peptide therapies are advancing rapidly. Manufacturing must keep pace.
As products move toward commercialization, manufacturers face increasing pressure to deliver:
- scale
- cost efficiency
- sustainability
Traditional approaches often rely heavily on end-stage purification, creating a significant manufacturing bottleneck.
This is one of the reasons why Liquid Phase Peptide Synthesis is gaining attention as a scalable and efficient route to peptide API manufacturing.
In this video, our colleagues Roberto Profeta and Deepshikha Angrish share why it matters.
How does FIS approach LPPS?
At FIS, LPPS starts with process chemistry. Our convergent strategies are designed to generate key peptide fragments with high purity, helping simplify downstream processing and support industrial scale-up. From clinical supply to commercial manufacturing, FIS combines:
- process chemistry expertise
- large-scale manufacturing capabilities
- a strong focus on purity and cost control.
Hear from Roberto Profeta and Deepshikha Angrish in this new video.
Innovation in LPPS requires the right enabling technologies. That’s why FIS developed FISTag™, our proprietary tagging platform designed to strengthen peptide manufacturing processes.
FISTag™ helps:
- support purity through controlled precipitation and crystallization
- improve solubility
- enable more efficient processing.
It also supports a more sustainable manufacturing approach, as the tag can be recovered and recycled at the end of synthesis.
In this video, Roberto Profeta and Deepshikha Angrish explain how FISTag™ enhances the FIS approach to peptide manufacturing.